MGP Database

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MGP001099

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, beta
Protein EntryFNTB_HUMAN
UniProt IDP49356
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49356-1; Sequence=Displayed; Name=2; IsoId=P49356-2; Sequence=VSP_054657; Note=No experimental confirmation available.;
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009};
FunctionEssential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.
InteractionP49354:FNTA; NbExp=7; IntAct=EBI-602349, EBI-602336;
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 5 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of FNTA and FNTB. {ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.
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