MGP Database

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MGP001344

Ontology/Pathway Information

Entrez Gene ID2932
Gene Nameglycogen synthase kinase 3 beta
Gene Symbol GSK3B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030877 IDA:UniProtKBCbeta-catenin destruction complex
GO:0005813 IDA:UniProtKBCcentrosome
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0043198 IEA:EnsemblCdendritic shaft
GO:0043197 IEA:EnsemblCdendritic spine
GO:0030426 IEA:EnsemblCgrowth cone
GO:0045121 IEA:EnsemblCmembrane raft
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0030529 IEA:EnsemblCribonucleoprotein complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008013 IPI:BHF-UCLFbeta-catenin binding
GO:0016301 IDA:UniProtKBFkinase activity
GO:0051059 IPI:UniProtKBFNF-kappaB binding
GO:0002039 IDA:MGIFp53 binding
GO:0034236 IPI:BHF-UCLFprotein kinase A catalytic subunit binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0001085 IPI:UniProtKBFRNA polymerase II transcription factor binding
GO:0050321 IDA:UniProtKBFtau-protein kinase activity
GO:0031625 IPI:BHF-UCLFubiquitin protein ligase binding
GO:0007411 TAS:ReactomePaxon guidance
GO:0060070 IC:UniProtKBPcanonical Wnt signaling pathway
GO:0044337 IEA:EnsemblPcanonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0016477 IEA:EnsemblPcell migration
GO:0036016 ISS:UniProtKBPcellular response to interleukin-3
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0007623 ISS:UniProtKBPcircadian rhythm
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0001837 IMP:UniProtKBPepithelial to mesenchymal transition
GO:0006983 IDA:MGIPER overload response
GO:0030010 IEA:EnsemblPestablishment of cell polarity
GO:0097192 ISS:UniProtKBPextrinsic apoptotic signaling pathway in absence of ligand
GO:0045444 IEA:EnsemblPfat cell differentiation
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0005977 IDA:BHF-UCLPglycogen metabolic process
GO:0021766 IMP:BHF-UCLPhippocampus development
GO:0044027 IEA:EnsemblPhypermethylation of CpG island
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 IDA:MGIPintracellular signal transduction
GO:0007520 IEA:EnsemblPmyoblast fusion
GO:0043066 IDA:MGIPnegative regulation of apoptotic process
GO:0090090 TAS:UniProtKBPnegative regulation of canonical Wnt signaling pathway
GO:0010614 IEA:EnsemblPnegative regulation of cardiac muscle hypertrophy
GO:0050774 IEA:EnsemblPnegative regulation of dendrite morphogenesis
GO:0045719 TAS:UniProtKBPnegative regulation of glycogen biosynthetic process
GO:2000466 TAS:UniProtKBPnegative regulation of glycogen (starch) synthase activity
GO:0043407 IEA:EnsemblPnegative regulation of MAP kinase activity
GO:0014043 IEA:EnsemblPnegative regulation of neuron maturation
GO:0051534 IMP:UniProtKBPnegative regulation of NFAT protein import into nucleus
GO:0032091 IDA:BHF-UCLPnegative regulation of protein binding
GO:0031333 IMP:BHF-UCLPnegative regulation of protein complex assembly
GO:2000077 TAS:UniProtKBPnegative regulation of type B pancreatic cell development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 IEA:EnsemblPorgan morphogenesis
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0001954 IMP:BHF-UCLPpositive regulation of cell-matrix adhesion
GO:1901030 ISS:UniProtKBPpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:0010800 IEA:EnsemblPpositive regulation of peptidyl-threonine phosphorylation
GO:0032436 IEA:EnsemblPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092 ISS:UniProtKBPpositive regulation of protein binding
GO:0045732 IC:BHF-UCLPpositive regulation of protein catabolic process
GO:0031334 IDA:BHF-UCLPpositive regulation of protein complex assembly
GO:0046827 IDA:MGIPpositive regulation of protein export from nucleus
GO:0032855 IMP:BHF-UCLPpositive regulation of Rac GTPase activity
GO:2000738 IEA:EnsemblPpositive regulation of stem cell differentiation
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0006611 IEA:EnsemblPprotein export from nucleus
GO:0035372 IEA:EnsemblPprotein localization to microtubule
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0000320 IEA:EnsemblPre-entry into mitotic cell cycle
GO:0006349 IEA:EnsemblPregulation of gene expression by genetic imprinting
GO:0032886 IMP:UniProtKBPregulation of microtubule-based process
GO:0048168 IEA:EnsemblPregulation of neuronal synaptic plasticity
GO:0042493 IEA:EnsemblPresponse to drug
GO:0010226 IEA:EnsemblPresponse to lithium ion
GO:0071109 IMP:BHF-UCLPsuperior temporal gyrus development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_18266Axon guidance
REACT_11065Beta-catenin phosphorylation cascade
REACT_120956Cellular responses to stress
REACT_263897Cellular response to heat stress
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19199CRMPs in Sema3A signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_267700Degradation of GLI2 by the proteasome
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_111045Developmental Biology
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_268323Hedgehog 'off' state
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_264487Regulation of HSF1-mediated heat shock response
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_19271Semaphorin interactions
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_264508Signaling by Hedgehog
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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