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MGP001480

UniProt Annotations

Entry Information

Gene Name	solute carrier family 29 (equilibrative nucleoside transporter), member 2
Protein Entry
UniProt ID	Q96FB2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q14542-1; Sequence=Displayed; Name=2; Synonyms=Short, HNP36; IsoId=Q14542-2; Sequence=VSP_040728, VSP_040729; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q14542-3; Sequence=VSP_040730, VSP_040731;
Biophysicochemical Properties	Kinetic parameters: KM=0.2 mM for uridine {ECO:0000269\|PubMed:12527552, ECO:0000269\|PubMed:9396714}; KM=0.75 mM for adenosine {ECO:0000269\|PubMed:12527552, ECO:0000269\|PubMed:9396714}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
Function	Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269\|PubMed:9396714}.
Induction	By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).
Sequence Caution	Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Similarity	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO:0000305}.
Subcellular Location	Basolateral cell membrane {ECO:0000269\|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269\|PubMed:12527552}. Nucleus membrane {ECO:0000269\|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269\|PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.
Tissue Specificity	Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO:0000269\|PubMed:12527552, ECO:0000269\|PubMed:9396714}.