MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001503

UniProt Annotations

Entry Information
Gene Nameheat shock factor binding protein 1
Protein EntryHSBP1_HUMAN
UniProt IDO75506
SpeciesHuman
Comments
Comment typeDescription
FunctionNegative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
SimilarityBelongs to the HSBP1 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitHomohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer. {ECO:0000269|PubMed:18767159}.
  logo