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MGP001538

UniProt Annotations

Entry Information

Gene Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Protein Entry	5HT7R_HUMAN
UniProt ID	P34969
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Comment=Isoform A and isoform B appear to be expressed at higher levels.; Name=D; IsoId=P34969-1; Sequence=Displayed; Name=A; IsoId=P34969-2; Sequence=VSP_001857; Name=B; IsoId=P34969-3; Sequence=VSP_001856;
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Similarity	Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression. {ECO:0000269\|PubMed:9084407}.