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MGP001604

Record overview

MGPD IDMGP001604
Gene ID3558
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 2
Gene Symbol IL2
SynonymsIL-2; TCGF; lymphokine;
Alternate namesinterleukin-2; T cell growth factor; aldesleukin; involved in regulation of T-cell clonal expansion;
Chromosome4
Map Location4q26-q27
SummaryThe protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IL2

Proteins

interleukin-2 precursor
Refseq ID:NP_000577
Protein GI:28178861
UniProt ID:P60568
mRNA ID:NM_000586
Length:153
RefSeq Status:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHL
RPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2228
peptide sequence: 
MYRMQLLSCIALSLALVTNS
 
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