MGP Database

MGP001616

Record overview

MGPD ID	MGP001616
Gene ID	3574
Species	Homo sapiens (Human)
Gene Name	interleukin 7
Gene Symbol	IL7
Synonyms	IL-7;
Alternate names	interleukin-7;
Chromosome	8
Map Location	8q12-q13
Summary	The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
Orthologs	View orthologs and multiple alignments for IL7

Proteins

interleukin-7 isoform 1 precursor

Refseq ID:	NP_000871
Protein GI:	4504677
UniProt ID:	P13232
mRNA ID:	NM_000880
Length:	177
RefSeq Status:

`MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDF DLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..133
product: interleukin-7 isoform 2
calculated_mol_wt: 12403
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNK
ILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..159
product: interleukin-7 isoform 3
calculated_mol_wt: 15554
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQEENKS
LKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..115
product: interleukin-7 isoform 4
calculated_mol_wt: 10570
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..177
product: interleukin-7 isoform 1
calculated_mol_wt: 17387
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRK
PAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

interleukin-7 isoform 2 precursor

Refseq ID:	NP_001186815
Protein GI:	315467867
UniProt ID:	P13232
mRNA ID:	NM_001199886
Length:	133
RefSeq Status:

`MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKVKGRKPAALGEAQPTKSLEENKSL KEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..133
product: interleukin-7 isoform 2
calculated_mol_wt: 12403
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNK
ILMGTKEH

interleukin-7 isoform 3 precursor

Refseq ID:	NP_001186816
Protein GI:	315467869
UniProt ID:	P13232
mRNA ID:	NM_001199887
Length:	159
RefSeq Status:

`MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDF DLHLLKVSEGTTILLNCTGQEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..133
product: interleukin-7 isoform 2
calculated_mol_wt: 12403
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNK
ILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..159
product: interleukin-7 isoform 3
calculated_mol_wt: 15554
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQEENKS
LKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

interleukin-7 isoform 4 precursor

Refseq ID:	NP_001186817
Protein GI:	315467871
UniProt ID:	P13232
mRNA ID:	NM_001199888
Length:	115
RefSeq Status:

`MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEENKSLKEQKKLNDLCFLKRLLQE IKTCWNKILMGTKEH`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..133
product: interleukin-7 isoform 2
calculated_mol_wt: 12403
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNK
ILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..159
product: interleukin-7 isoform 3
calculated_mol_wt: 15554
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQEENKS
LKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2817
peptide sequence: 
MFHVSFRYIFGLPPLILVLLPVASS

mat_peptide: 26..115
product: interleukin-7 isoform 4
calculated_mol_wt: 10570
peptide sequence: 
DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH