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MGP001621

UniProt Annotations

Entry Information
Gene Nameinterleukin 13
Protein EntryIL13_HUMAN
UniProt IDP35225
SpeciesHuman
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-15 is the initiator. {ECO:0000305}.
DiseaseAllergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionCytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
InteractionP78552:IL13RA1; NbExp=4; IntAct=EBI-1647828, EBI-1391535;
Sequence CautionSequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the IL-4/IL-13 family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitInteracts with IL13RA2. {ECO:0000269|PubMed:20223216}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il13/";
Web ResourceName=Wikipedia; Note=Interleukin-13 entry; URL="http://en.wikipedia.org/wiki/Interleukin_13";
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