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MGP001679

UniProt Annotations

Entry Information
Gene Nameintegrin, beta 8
Protein EntryITB8_HUMAN
UniProt IDP26012
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P26012-1; Sequence=Displayed; Name=2; IsoId=P26012-2; Sequence=VSP_056531; Note=No experimental confirmation available.;
FunctionIntegrin alpha-V/beta-8 is a receptor for fibronectin.
SimilarityBelongs to the integrin beta chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.
Tissue SpecificityPlacenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
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