MGP Database

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MGP001705

UniProt Annotations

Entry Information
Gene Namepotassium channel, voltage gated shaker related subfamily A, member 7
Protein EntryKCNA7_HUMAN
UniProt IDQ96RP8
SpeciesHuman
Comments
Comment typeDescription
DomainThe N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. {ECO:0000250}.
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. {ECO:0000250}.
FunctionMediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}.
SimilarityBelongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHeterotetramer of potassium channel proteins. {ECO:0000250}.
Tissue SpecificityHighly expressed in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:11368907, ECO:0000269|PubMed:11896454}.
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