MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001767

UniProt Annotations

Entry Information
Gene Namekallikrein-related peptidase 2
Protein EntryKLK2_HUMAN
UniProt IDP20151
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P20151-1; Sequence=Displayed; Name=2; Synonyms=PGK-10A; IsoId=P20151-2; Sequence=VSP_005399; Note=Ref.6 (BAG62272) sequence is in conflict in position: 223:G->GE. {ECO:0000305}; Name=3; IsoId=P20151-3; Sequence=VSP_005400; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=P20151-4; Sequence=VSP_044709; Note=No experimental confirmation available.;
Catalytic ActivityPreferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
FunctionGlandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Sequence CautionSequence=AAD13817.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase S1 family. Kallikrein subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
  logo