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MGP001773

UniProt Annotations

Entry Information
Gene Namekinesin light chain 1
Protein EntryKLC1_HUMAN
UniProt IDQ07866
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=10; Comment=Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms.; Name=A; IsoId=Q07866-1; Sequence=Displayed; Name=C; Synonyms=KLC1C, R, KLC1R; IsoId=Q07866-2; Sequence=VSP_008018; Name=G; Synonyms=KLC1G; IsoId=Q07866-3; Sequence=VSP_008017; Name=J; Synonyms=KLC1J; IsoId=Q07866-4; Sequence=VSP_008019, VSP_008020; Note=Ref.2 (AAO62555) sequence is in conflict in position: 631:S->T. Contains a phosphoserine at position 600. Contains a phosphoserine at position 631. {ECO:0000305}; Name=K; Synonyms=KLC1K; IsoId=Q07866-5; Sequence=VSP_008019; Name=N; Synonyms=KLC1N; IsoId=Q07866-6; Sequence=VSP_008017, VSP_008019, VSP_008020; Note=Ref.2 (AAO62551) sequence is in conflict in position: 622:S->T. Contains a phosphoserine at position 591. Contains a phosphoserine at position 622. {ECO:0000305}; Name=P; Synonyms=KLC1P; IsoId=Q07866-7; Sequence=VSP_008021; Note=Contains a phosphoserine at position 547. Contains a phosphoserine at position 578.; Name=S; Synonyms=KLC1S, Q, KLC1Q; IsoId=Q07866-8; Sequence=VSP_008017, VSP_008018; Name=I; IsoId=Q07866-9; Sequence=VSP_023323; Note=Contains a phosphoserine at position 600.; Name=D; Synonyms=KLC1D; IsoId=Q07866-10; Sequence=VSP_046424;
CautionIt is uncertain whether Met-1 or Met-5 is the initiator. {ECO:0000305}.
FunctionKinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
PtmIsoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631. {ECO:0000269|PubMed:20074060}.
Sequence CautionSequence=AAA16576.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF72543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO62549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01268.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01291.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01292.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01295.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01296.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the kinesin light chain family. {ECO:0000305}.
SimilarityContains 6 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular LocationCell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}.
SubunitOligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell. {ECO:0000269|PubMed:14970196, ECO:0000269|PubMed:21925109}.
Tissue SpecificityFound in a variety of tissues. Mostly abundant in brain and spine. {ECO:0000269|PubMed:14970196}.
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