MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001801

Record overview

MGPD IDMGP001801
Gene ID3930
SpeciesHomo sapiens (Human)
Gene Namelamin B receptor
Gene Symbol LBR
SynonymsPHA; LMN2R; TDRD18; DHCR14B;
Alternate nameslamin-B receptor; integral nuclear envelope inner membrane protein; tudor domain containing 18;
Chromosome1
Map Location1q42.1
SummaryThe protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LBR

Proteins

lamin-B receptor
Refseq ID:NP_002287
Protein GI:37595750
UniProt ID:Q14739
mRNA ID:NM_002296
Length:615
RefSeq Status:
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASA
SHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVT
PIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVIN
LVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVI
FRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
KYCQRVPYRIFPYIY
 
lamin-B receptor
Refseq ID:NP_919424
Protein GI:37595752
UniProt ID:Q14739
mRNA ID:NM_194442
Length:615
RefSeq Status:
Protein sequence is identical to GI:37595750 (mRNA isoform)
 
  logo