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MGP001814

UniProt Annotations

Entry Information
Gene Nameluteinizing hormone beta polypeptide
Protein EntryLSHB_HUMAN
UniProt IDP01229
SpeciesHuman
Comments
Comment typeDescription
DiseaseHypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. {ECO:0000269|PubMed:1727547}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionPromotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
SimilarityBelongs to the glycoprotein hormones subunit beta family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHeterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
Tissue SpecificityPituitary gland.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LHB";
Web ResourceName=Wikipedia; Note=Luteinizing hormone entry; URL="http://en.wikipedia.org/wiki/Luteinizing_hormone";
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