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MGP001817

UniProt Annotations

Entry Information
Gene Nameligase III, DNA, ATP-dependent
Protein EntryDNLI3_HUMAN
UniProt IDP49916
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=4; Name=1; IsoId=P49916-1; Sequence=Displayed; Note=Produced by alternative splicing.; Name=2; IsoId=P49916-2; Sequence=VSP_001302; Note=Produced by alternative splicing.; Name=3; Synonyms=Alpha; IsoId=P49916-3; Sequence=VSP_057464; Note=Produced by alternative initiation of isoform 1.; Name=4; Synonyms=Beta; IsoId=P49916-4; Sequence=VSP_057464, VSP_001302; Note=Produced by alternative initiation of isoform 2.;
Catalytic ActivityATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). {ECO:0000255|PROSITE-ProRule:PRU10135, ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:20518483}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
DomainThe PARP-type zinc finger is required for DNA ligase activity. {ECO:0000269|PubMed:20518483}.
FunctionIsoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
SimilarityBelongs to the ATP-dependent DNA ligase family. {ECO:0000305}.
SimilarityContains 1 BRCT domain. {ECO:0000255|PROSITE- ProRule:PRU00033}.
SimilarityContains 1 PARP-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00264}.
Subcellular LocationIsoform 1: Mitochondrion {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.
Subcellular LocationIsoform 2: Mitochondrion {ECO:0000305|PubMed:10207110}. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}.
Subcellular LocationIsoform 3: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.
Subcellular LocationIsoform 4: Nucleus {ECO:0000305|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000305|PubMed:10207110}.
SubunitIsoform 3 interacts (via BRCT domain) with the nuclear DNA-repair protein XRCC1. {ECO:0000269|PubMed:21652643, ECO:0000269|PubMed:7760816}.
Tissue SpecificityTestis, thymus, prostate and heart.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mpg/";
Web ResourceName=Wikipedia; Note=DNA ligase entry; URL="http://en.wikipedia.org/wiki/DNA_ligase";
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