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MGP001821

UniProt Annotations

Entry Information
Gene NameLIM domain kinase 2
Protein EntryLIMK2_HUMAN
UniProt IDP53671
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=LIMK2a; IsoId=P53671-1; Sequence=Displayed; Name=LIMK2b; IsoId=P53671-2; Sequence=VSP_012287; Name=3; IsoId=P53671-3; Sequence=VSP_012287, VSP_043332; Note=No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
FunctionDisplays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042}.
InteractionP08238:HSP90AB1; NbExp=2; IntAct=EBI-1384350, EBI-352572;
PtmPhosphorylated on serine and/or threonine residues by ROCK1. {ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18691976}.
Sequence CautionSequence=AAB54055.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. {ECO:0000305}.
SimilarityContains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 2 LIM zinc-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00125}.
Subcellular LocationIsoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus.
Subcellular LocationIsoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
SubunitBinds ROCK1 and LKAP. Interacts with PARD3. Interacts with NISCH (By similarity). {ECO:0000250}.
Tissue SpecificityHighest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. {ECO:0000269|PubMed:8954941}.
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