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MGP001822

Record overview

MGPD IDMGP001822
Gene ID3987
SpeciesHomo sapiens (Human)
Gene NameLIM and senescent cell antigen-like domains 1
Gene Symbol LIMS1
SynonymsPINCH; PINCH1; PINCH-1;
Alternate namesLIM and senescent cell antigen-like-containing domain protein 1; particularly interesting new Cys-His protein 1; renal carcinoma antigen NY-REN-48;
Chromosome2
Map Location2q12.3
SummaryThe protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
OrthologsView orthologs and multiple alignments for LIMS1

Proteins

LIM and senescent cell antigen-like-containing domain protein 1 isoform a
Refseq ID:NP_001180414
Protein GI:301601611
UniProt ID:P48059
mRNA ID:NM_001193485
Length:387
RefSeq Status:
MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVC
AQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKC
HAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLA
YCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
 
LIM and senescent cell antigen-like-containing domain protein 1 isoform b
Refseq ID:NP_004978
Protein GI:13518026
UniProt ID:P48059
mRNA ID:NM_004987
Length:325
RefSeq Status:
MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLC
QEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPI
EGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVC
KKCYEKFPLELKKRLKKLAETLGRK
 
LIM and senescent cell antigen-like-containing domain protein 1 isoform b
Refseq ID:NP_001180417
Protein GI:301601630
UniProt ID:P48059
mRNA ID:NM_001193488
Length:325
RefSeq Status:
Protein sequence is identical to GI:13518026 (mRNA isoform)
 
LIM and senescent cell antigen-like-containing domain protein 1 isoform c
Refseq ID:NP_001180411
Protein GI:301601605
UniProt ID:P48059
mRNA ID:NM_001193482
Length:329
RefSeq Status:
MTCNMANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFR
CDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGAC
RRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDM
KPVCKKCYEKFPLELKKRLKKLAETLGRK
 
LIM and senescent cell antigen-like-containing domain protein 1 isoform d
Refseq ID:NP_001180412
Protein GI:301601607
UniProt ID:P48059
mRNA ID:NM_001193483
Length:337
RefSeq Status:
MLGVAAGMTHSNMANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNN
SWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKM
GVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLK
NKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
 
LIM and senescent cell antigen-like-containing domain protein 1 isoform e
Refseq ID:NP_001180413
Protein GI:301601609
UniProt ID:P48059
mRNA ID:NM_001193484
Length:362
RefSeq Status:
MTALQLKELSHSGLYRRRRDRPDSLRVNGLPEEELSNMANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDF
QMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCAN
CGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDV
VSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
 
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