MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001849

Ontology/Pathway Information

Entrez Gene ID4067
Gene NameLYN proto-oncogene, Src family tyrosine kinase
Gene Symbol LYN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0034666 IEA:EnsemblCintegrin alpha2-beta1 complex
GO:0042629 IEA:EnsemblCmast cell granule
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0030061 IEA:EnsemblCmitochondrial crista
GO:0005758 IEA:EnsemblCmitochondrial intermembrane space
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0043208 IEA:EnsemblFglycosphingolipid binding
GO:0044325 IPI:BHF-UCLFion channel binding
GO:0004715 IBA:GO_CentralFnon-membrane spanning protein tyrosine kinase activity
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0005102 IBA:GO_CentralFreceptor binding
GO:0004716 TAS:ProtIncFreceptor signaling protein tyrosine kinase activity
GO:0001782 ISS:UniProtKBPB cell homeostasis
GO:0050853 IEA:EnsemblPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0031668 IEA:EnsemblPcellular response to extracellular stimulus
GO:0034605 IEA:EnsemblPcellular response to heat
GO:0071375 IBA:GO_CentralPcellular response to peptide hormone stimulus
GO:0071300 IMP:BHF-UCLPcellular response to retinoic acid
GO:0007417 IBA:GO_CentralPcentral nervous system development
GO:0050663 IEA:EnsemblPcytokine secretion
GO:0097028 ISS:UniProtKBPdendritic cell differentiation
GO:0030218 ISS:UniProtKBPerythrocyte differentiation
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0002774 ISS:UniProtKBPFc receptor mediated inhibitory signaling pathway
GO:0002431 ISS:UniProtKBPFc receptor mediated stimulatory signaling pathway
GO:0002553 IEA:EnsemblPhistamine secretion by mast cell
GO:0002768 ISS:UniProtKBPimmune response-regulating cell surface receptor signaling pathway
GO:0006954 IBA:GO_CentralPinflammatory response
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0031663 ISS:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0030889 IBA:GO_CentralPnegative regulation of B cell proliferation
GO:0008285 IMP:UniProtKBPnegative regulation of cell proliferation
GO:0070373 ISS:UniProtKBPnegative regulation of ERK1 and ERK2 cascade
GO:0050777 TAS:UniProtKBPnegative regulation of immune response
GO:1902532 ISS:UniProtKBPnegative regulation of intracellular signal transduction
GO:0043407 ISS:UniProtKBPnegative regulation of MAP kinase activity
GO:0070667 ISS:UniProtKBPnegative regulation of mast cell proliferation
GO:0002762 IEA:EnsemblPnegative regulation of myeloid leukocyte differentiation
GO:0001933 ISS:UniProtKBPnegative regulation of protein phosphorylation
GO:0034136 ISS:UniProtKBPnegative regulation of toll-like receptor 2 signaling pathway
GO:0034144 ISS:UniProtKBPnegative regulation of toll-like receptor 4 signaling pathway
GO:0031175 IEA:EnsemblPneuron projection development
GO:0014003 IEA:EnsemblPoligodendrocyte development
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 ISS:UniProtKBPplatelet degranulation
GO:0050861 IEA:EnsemblPpositive regulation of B cell receptor signaling pathway
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 ISS:UniProtKBPpositive regulation of cell proliferation
GO:0051272 IDA:UniProtKBPpositive regulation of cellular component movement
GO:2000670 ISS:UniProtKBPpositive regulation of dendritic cell apoptotic process
GO:0060369 IEA:EnsemblPpositive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060252 IEA:EnsemblPpositive regulation of glial cell proliferation
GO:0070668 IMP:UniProtKBPpositive regulation of mast cell proliferation
GO:0010976 IMP:BHF-UCLPpositive regulation of neuron projection development
GO:0070447 IEA:EnsemblPpositive regulation of oligodendrocyte progenitor proliferation
GO:0043552 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0070304 IDA:UniProtKBPpositive regulation of stress-activated protein kinase signaling cascade
GO:0042531 ISS:UniProtKBPpositive regulation of tyrosine phosphorylation of STAT protein
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0002902 IBA:GO_CentralPregulation of B cell apoptotic process
GO:0050855 ISS:UniProtKBPregulation of B cell receptor signaling pathway
GO:0033628 IMP:UniProtKBPregulation of cell adhesion mediated by integrin
GO:0001817 ISS:UniProtKBPregulation of cytokine production
GO:0050707 IEA:EnsemblPregulation of cytokine secretion
GO:0070372 ISS:UniProtKBPregulation of ERK1 and ERK2 cascade
GO:0045646 ISS:UniProtKBPregulation of erythrocyte differentiation
GO:0050727 IEA:EnsemblPregulation of inflammatory response
GO:0033003 ISS:UniProtKBPregulation of mast cell activation
GO:0043304 ISS:UniProtKBPregulation of mast cell degranulation
GO:0090025 IMP:UniProtKBPregulation of monocyte chemotaxis
GO:0090330 ISS:UniProtKBPregulation of platelet aggregation
GO:0001932 TAS:UniProtKBPregulation of protein phosphorylation
GO:0051279 IEA:EnsemblPregulation of release of sequestered calcium ion into cytosol
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0048678 IEA:EnsemblPresponse to axon injury
GO:0009743 IEA:EnsemblPresponse to carbohydrate
GO:0042493 IEA:EnsemblPresponse to drug
GO:0009725 ISS:UniProtKBPresponse to hormone
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0006991 IEA:EnsemblPresponse to sterol depletion
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0007165 TAS:ProtIncPsignal transduction
GO:0023014 TAS:GOCPsignal transduction by phosphorylation
GO:0031295 TAS:ReactomePT cell costimulation
GO:0002513 ISS:UniProtKBPtolerance induction to self antigen
GO:0007169 IMP:UniProtKBPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_18266Axon guidance
REACT_19183CD28 co-stimulation
REACT_12051Cell surface interactions at the vascular wall
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_75790Cytokine Signaling in Immune system
REACT_111045Developmental Biology
REACT_264548EPHA-mediated growth cone collapse
REACT_263952EPHB-mediated forward signaling
REACT_264198EPH-ephrin mediated repulsion of cells
REACT_264068EPH-Ephrin signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_163994FCERI mediated NF-kB activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160274FCGR activation
REACT_1695GPVI-mediated activation cascade
REACT_111133Growth hormone receptor signaling
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_12519PECAM1 interactions
REACT_798Platelet activation, signaling and aggregation
REACT_1230Platelet Adhesion to exposed collagen
REACT_111225Regulation of KIT signaling
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_22232Signaling by Interleukins
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
  logo