MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001858

Ontology/Pathway Information

Entrez Gene ID4091
Gene NameSMAD family member 6
Gene Symbol SMAD6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:BHF-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:MGICprotein complex
GO:0005667 IEA:InterProCtranscription factor complex
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0070410 IPI:BHF-UCLFco-SMAD binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0070411 IPI:BHF-UCLFI-SMAD binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0070412 IPI:BHF-UCLFR-SMAD binding
GO:0003700 IEA:InterProFsequence-specific DNA binding transcription factor activity
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0030617 IDA:BHF-UCLFtransforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0070698 IDA:BHF-UCLFtype I activin receptor binding
GO:0034713 IDA:BHF-UCLFtype I transforming growth factor beta receptor binding
GO:0031625 IPI:BHF-UCLFubiquitin protein ligase binding
GO:0030509 IDA:UniProtKBPBMP signaling pathway
GO:0031589 IMP:UniProtKBPcell-substrate adhesion
GO:0045444 IDA:UniProtKBPfat cell differentiation
GO:0006955 IMP:BHF-UCLPimmune response
GO:0035556 IDA:GOCPintracellular signal transduction
GO:0043066 IMP:BHF-UCLPnegative regulation of apoptotic process
GO:0030514 IDA:BHF-UCLPnegative regulation of BMP signaling pathway
GO:0008285 IMP:BHF-UCLPnegative regulation of cell proliferation
GO:0060394 IDA:BHF-UCLPnegative regulation of pathway-restricted SMAD protein phosphorylation
GO:0010991 IDA:BHF-UCLPnegative regulation of SMAD protein complex assembly
GO:0030512 IMP:BHF-UCLPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0034616 IEP:BHF-UCLPresponse to laminar fluid shear stress
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0007179 IEA:InterProPtransforming growth factor beta receptor signaling pathway
GO:0001657 IEA:EnsemblPureteric bud development
GO:0007352 IMP:BHF-UCLPzygotic specification of dorsal/ventral axis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12034Signaling by BMP
REACT_111102Signal Transduction
  logo