MGP Database

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MGP001859

Ontology/Pathway Information

Entrez Gene ID4092
Gene NameSMAD family member 7
Gene Symbol SMAD7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0043234 IDA:MGICprotein complex
GO:0005667 IEA:InterProCtranscription factor complex
GO:0048185 IPI:BHF-UCLFactivin binding
GO:0008013 IPI:BHF-UCLFbeta-catenin binding
GO:0070411 IPI:BHF-UCLFI-SMAD binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0003700 IEA:InterProFsequence-specific DNA binding transcription factor activity
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0030617 IDA:BHF-UCLFtransforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0034713 IPI:BHF-UCLFtype I transforming growth factor beta receptor binding
GO:0031625 IPI:BHF-UCLFubiquitin protein ligase binding
GO:0034333 IMP:BHF-UCLPadherens junction assembly
GO:0048844 ISS:BHF-UCLPartery morphogenesis
GO:0030509 TAS:ReactomePBMP signaling pathway
GO:0034629 IDA:BHF-UCLPcellular protein complex localization
GO:0071560 IMP:BHF-UCLPcellular response to transforming growth factor beta stimulus
GO:0010467 TAS:ReactomePgene expression
GO:0030514 IDA:BHF-UCLPnegative regulation of BMP signaling pathway
GO:0030336 TAS:BHF-UCLPnegative regulation of cell migration
GO:0010719 TAS:BHF-UCLPnegative regulation of epithelial to mesenchymal transition
GO:0060394 IDA:BHF-UCLPnegative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137 IDA:BHF-UCLPnegative regulation of peptidyl-serine phosphorylation
GO:0010801 IDA:BHF-UCLPnegative regulation of peptidyl-threonine phosphorylation
GO:0031397 IDA:BHF-UCLPnegative regulation of protein ubiquitination
GO:0043433 IDA:BHF-UCLPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0010944 IDA:BHF-UCLPnegative regulation of transcription by competitive promoter binding
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0030512 IDA:BHF-UCLPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0051444 IDA:BHF-UCLPnegative regulation of ubiquitin-protein transferase activity
GO:0060389 ISS:BHF-UCLPpathway-restricted SMAD protein phosphorylation
GO:0022409 IDA:BHF-UCLPpositive regulation of cell-cell adhesion
GO:0032436 IDA:BHF-UCLPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IDA:BHF-UCLPpositive regulation of protein ubiquitination
GO:0045944 TAS:ReactomePpositive regulation of transcription from RNA polymerase II promoter
GO:0050821 IDA:BHF-UCLPprotein stabilization
GO:0032925 IDA:BHF-UCLPregulation of activin receptor signaling pathway
GO:0055117 ISS:BHF-UCLPregulation of cardiac muscle contraction
GO:0017015 IC:BHF-UCLPregulation of transforming growth factor beta receptor signaling pathway
GO:0060373 IC:BHF-UCLPregulation of ventricular cardiac muscle cell membrane depolarization
GO:0034616 IEP:BHF-UCLPresponse to laminar fluid shear stress
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0001657 IEA:EnsemblPureteric bud development
GO:0055010 ISS:BHF-UCLPventricular cardiac muscle tissue morphogenesis
GO:0060412 ISS:BHF-UCLPventricular septum morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_12034Signaling by BMP
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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