MGP Database

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MGP001895

Ontology/Pathway Information

Entrez Gene ID4193
Gene NameMDM2 proto-oncogene, E3 ubiquitin protein ligase
Gene Symbol MDM2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005634 IEA:InterProCnucleus
GO:0043066 IEA:InterProPnegative regulation of apoptotic process
GO:0071157 IEA:InterProPnegative regulation of cell cycle arrest
GO:0000122 IEA:InterProPnegative regulation of transcription from RNA polymerase II promoter
GO:0016567 IEA:InterProPprotein ubiquitination
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_2254G1/S DNA Damage Checkpoints
REACT_12578GAB1 signalosome
REACT_18347Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_309Stabilization of p53
REACT_18307Trafficking of AMPA receptors
REACT_13477Transmission across Chemical Synapses
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