MGP Database

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MGP001914

UniProt Annotations

Entry Information
Gene Namemilk fat globule-EGF factor 8 protein
Protein EntryMFGM_HUMAN
UniProt IDQ08431
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q08431-1; Sequence=Displayed; Name=2; IsoId=Q08431-2; Sequence=VSP_039108; Note=No experimental confirmation available.; Name=3; IsoId=Q08431-3; Sequence=VSP_039953;
DomainThe F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes. {ECO:0000250}.
FunctionMedin is the main constituent of aortic medial amyloid. {ECO:0000269|PubMed:19204935}.
FunctionPlays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. {ECO:0000250, ECO:0000269|PubMed:19204935}.
PtmMedin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
SimilarityContains 1 EGF-like domain. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 2 F5/8 type C domains. {ECO:0000255|PROSITE- ProRule:PRU00081}.
Subcellular LocationMembrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}.
Tissue SpecificityMammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
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