MGP Database

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MGP002005

UniProt Annotations

Entry Information
Gene Namemyosin, heavy chain 4, skeletal muscle
Protein EntryMYH4_HUMAN
UniProt IDQ9Y623
SpeciesHuman
Comments
Comment typeDescription
CautionRepresents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4). {ECO:0000305}.
DomainEach myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
DomainThe rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
FunctionMuscle contraction.
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
SimilarityContains 1 IQ domain. {ECO:0000255|PROSITE- ProRule:PRU00116}.
SimilarityContains 1 myosin motor domain. {ECO:0000305}.
Subcellular LocationCytoplasm, myofibril. Note=Thick filaments of the myofibrils.
SubunitMuscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
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