MGP Database

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MGP002021

UniProt Annotations

Entry Information
Gene Namemyosin IXA
Protein EntryMYO9A_HUMAN
UniProt IDB2RTY4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=B2RTY4-1; Sequence=Displayed; Name=2; IsoId=B2RTY4-2; Sequence=VSP_035157; Note=No experimental confirmation available.; Name=3; IsoId=B2RTY4-3; Sequence=VSP_035158, VSP_035159; Note=No experimental confirmation available.; Name=4; IsoId=B2RTY4-4; Sequence=VSP_035160; Name=5; IsoId=B2RTY4-5; Sequence=VSP_035156; Note=Lacks the ATP-binding domain which suggests that it cannot interact with actin.;
CautionRepresents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9). {ECO:0000305}.
FunctionMyosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAA91979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14517.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
SimilarityContains 1 myosin motor domain. {ECO:0000305}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
SimilarityContains 5 IQ domains. {ECO:0000255|PROSITE- ProRule:PRU00116}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityFound to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis. {ECO:0000269|PubMed:10409426}.
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