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MGP002140

UniProt Annotations

Entry Information
Gene Namereceptor tyrosine kinase-like orphan receptor 1
Protein EntryROR1_HUMAN
UniProt IDQ01973
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Long; IsoId=Q01973-1; Sequence=Displayed; Name=Short; Synonyms=T-ROR1; IsoId=Q01973-2; Sequence=VSP_005008; Name=3; IsoId=Q01973-3; Sequence=VSP_043663, VSP_043664; Note=No experimental confirmation available.;
Catalytic ActivityATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
Developmental StageExpressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
FunctionTyrosine-protein kinase receptor whose role is not yet clear.
InteractionP00533:EGFR; NbExp=8; IntAct=EBI-6082337, EBI-297353; P12931:SRC; NbExp=9; IntAct=EBI-6082337, EBI-621482; P05480:Src (xeno); NbExp=3; IntAct=EBI-6082337, EBI-298680;
SimilarityBelongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
SimilarityContains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE- ProRule:PRU00090}.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 1 kringle domain. {ECO:0000255|PROSITE- ProRule:PRU00121}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
Tissue SpecificityExpressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
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