MGP Database

MGP002204

Ontology/Pathway Information

Entrez Gene ID	5080
Gene Name	paired box 6
Gene Symbol	PAX6
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0000790	IDA:BHF-UCL	C	nuclear chromatin
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0003680	IEA:Ensembl	F	AT DNA binding
GO:0003682	IEA:Ensembl	F	chromatin binding
GO:0003677	TAS:ProtInc	F	DNA binding
GO:0003690	IEA:Ensembl	F	double-stranded DNA binding
GO:0035035	ISS:BHF-UCL	F	histone acetyltransferase binding
GO:0019901	ISS:BHF-UCL	F	protein kinase binding
GO:0000978	IEA:Ensembl	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	IEA:Ensembl	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979	IDA:BHF-UCL	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0070412	IPI:BHF-UCL	F	R-SMAD binding
GO:0000981	IDA:BHF-UCL	F	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	TAS:ProtInc	F	sequence-specific DNA binding transcription factor activity
GO:0008134	ISS:BHF-UCL	F	transcription factor binding
GO:0004842	ISS:UniProtKB	F	ubiquitin-protein transferase activity
GO:0048708	IEA:Ensembl	P	astrocyte differentiation
GO:0007411	IEA:Ensembl	P	axon guidance
GO:0001568	IMP:DFLAT	P	blood vessel development
GO:0001709	IEA:Ensembl	P	cell fate determination
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0044344	IEA:Ensembl	P	cellular response to fibroblast growth factor stimulus
GO:0071333	IEA:Ensembl	P	cellular response to glucose stimulus
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0071380	IEA:Ensembl	P	cellular response to prostaglandin E stimulus
GO:0007417	TAS:ProtInc	P	central nervous system development
GO:0021549	IEA:Ensembl	P	cerebellum development
GO:0021796	IEA:Ensembl	P	cerebral cortex regionalization
GO:0021902	IEA:Ensembl	P	commitment of neuronal cell to specific neuron type in forebrain
GO:0061303	IMP:DFLAT	P	cornea development in camera-type eye
GO:0009950	IEA:Ensembl	P	dorsal/ventral axis specification
GO:0048596	IEA:Ensembl	P	embryonic camera-type eye morphogenesis
GO:0001654	TAS:ProtInc	P	eye development
GO:0042462	IEA:Ensembl	P	eye photoreceptor cell development
GO:0021797	IEA:Ensembl	P	forebrain anterior/posterior pattern specification
GO:0021798	IEA:Ensembl	P	forebrain dorsal/ventral pattern formation
GO:0021905	IEA:Ensembl	P	forebrain-midbrain boundary formation
GO:0042593	IMP:DFLAT	P	glucose homeostasis
GO:1901142	IEA:Ensembl	P	insulin metabolic process
GO:0022027	IEA:Ensembl	P	interkinetic nuclear migration
GO:0061072	IMP:DFLAT	P	iris morphogenesis
GO:0030216	IEA:Ensembl	P	keratinocyte differentiation
GO:0032808	IEA:Ensembl	P	lacrimal gland development
GO:0002088	IEA:Ensembl	P	lens development in camera-type eye
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0050768	ISS:UniProtKB	P	negative regulation of neurogenesis
GO:0045665	IEA:Ensembl	P	negative regulation of neuron differentiation
GO:0001755	IEA:Ensembl	P	neural crest cell migration
GO:0048663	NAS:UniProtKB	P	neuron fate commitment
GO:0001764	IEA:Ensembl	P	neuron migration
GO:0021772	IEA:Ensembl	P	olfactory bulb development
GO:0021778	IEA:Ensembl	P	oligodendrocyte cell fate specification
GO:0009887	TAS:ProtInc	P	organ morphogenesis
GO:0003322	IMP:BHF-UCL	P	pancreatic A cell development
GO:0021983	IEA:Ensembl	P	pituitary gland development
GO:0042660	IEA:Ensembl	P	positive regulation of cell fate specification
GO:0030858	IEA:Ensembl	P	positive regulation of epithelial cell differentiation
GO:0010628	IMP:BHF-UCL	P	positive regulation of gene expression
GO:0070094	IEA:Ensembl	P	positive regulation of glucagon secretion
GO:0002052	IEA:Ensembl	P	positive regulation of neuroblast proliferation
GO:2001224	IEA:Ensembl	P	positive regulation of neuron migration
GO:0045893	IMP:BHF-UCL	P	positive regulation of transcription, DNA-templated
GO:0045944	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0033365	IEA:Ensembl	P	protein localization to organelle
GO:0016567	ISS:GOC	P	protein ubiquitination
GO:0010975	IEA:Ensembl	P	regulation of neuron projection development
GO:0048505	IEA:Ensembl	P	regulation of timing of cell differentiation
GO:0021918	IEA:Ensembl	P	regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
GO:0021912	IEA:Ensembl	P	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913	IEA:Ensembl	P	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0009611	IEP:UniProtKB	P	response to wounding
GO:0060041	IEA:Ensembl	P	retina development in camera-type eye
GO:0021593	IEA:Ensembl	P	rhombomere morphogenesis
GO:0007435	IEA:Ensembl	P	salivary gland morphogenesis
GO:0023019	IEA:Ensembl	P	signal transduction involved in regulation of gene expression
GO:0007224	IEA:Ensembl	P	smoothened signaling pathway
GO:0006366	IMP:BHF-UCL	P	transcription from RNA polymerase II promoter
GO:0003309	IEA:Ensembl	P	type B pancreatic cell differentiation
GO:0007601	TAS:ProtInc	P	visual perception

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111045	Developmental Biology
REACT_23974	Incretin synthesis, secretion, and inactivation
REACT_17015	Metabolism of proteins
REACT_160078	Peptide hormone metabolism
REACT_13698	Regulation of beta-cell development
REACT_13819	Regulation of gene expression in beta cells
REACT_24019	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23824	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)