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MGP002212

Record overview

MGPD IDMGP002212
Gene ID5104
SpeciesHomo sapiens (Human)
Gene Nameserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Gene Symbol SERPINA5
SynonymsPCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3;
Alternate namesplasma serine protease inhibitor; acrosomal serine protease inhibitor; plasminogen activator inhibitor III; plasminogen activator inhibitor-3; protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5;
Chromosome14
Map Location14q32.1
SummaryThe protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
OrthologsView orthologs and multiple alignments for SERPINA5

Proteins

plasma serine protease inhibitor preproprotein
Refseq ID:NP_000615
Protein GI:194018472
UniProt ID:P05154
mRNA ID:NM_000624
Length:406
RefSeq Status:
MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQ
KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMV
NYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLE
LYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFL
GKVNRP
 
sig_peptide: 1..19
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P05154.3)
calculated_mol_wt: 2060
peptide sequence: 
MQLFLLLCLVLLSPQGASL

mat_peptide: 26..406
product: Plasma serine protease inhibitor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P05154.3)
calculated_mol_wt: 42812
peptide sequence: 
EMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGF
QLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV
TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISN
VFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRP
 
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