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MGP002248

UniProt Annotations

Entry Information
Gene Nameprefoldin subunit 4
Protein EntryPFD4_HUMAN
UniProt IDQ9NQP4
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
SimilarityBelongs to the prefoldin subunit beta family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.
SubunitHeterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner. {ECO:0000269|PubMed:17936702}.
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