MGP Database

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MGP002253

UniProt Annotations

Entry Information
Gene Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Protein EntryF263_HUMAN
UniProt IDQ16875
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q16875-1; Sequence=Displayed; Name=2; IsoId=Q16875-2; Sequence=VSP_004680; Name=3; IsoId=Q16875-3; Sequence=VSP_047165; Note=Gene prediction based on EST data.; Name=4; IsoId=Q16875-4; Sequence=VSP_054549; Note=No experimental confirmation available.;
Catalytic ActivityATP + D-fructose 6-phosphate = ADP + beta-D- fructose 2,6-bisphosphate.
Catalytic ActivityBeta-D-fructose 2,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate.
FunctionSynthesis and degradation of fructose 2,6-bisphosphate.
PtmPhosphorylation by AMPK stimulates activity. {ECO:0000269|PubMed:12065600, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231}.
SimilarityIn the C-terminal section; belongs to the phosphoglycerate mutase family. {ECO:0000305}.
Tissue SpecificityUbiquitous.
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