MGP Database

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MGP002291

Ontology/Pathway Information

Entrez Gene ID5291
Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene Symbol PIK3CB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005942 IBA:GO_CentralCphosphatidylinositol 3-kinase complex
GO:0005886 IBA:GO_CentralCplasma membrane
GO:0016303 IBA:GO_CentralF1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:GO_CentralF1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0035004 TAS:UniProtKBFphosphatidylinositol 3-kinase activity
GO:0046934 IBA:GO_CentralFphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0000187 TAS:ProtIncPactivation of MAPK activity
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0007596 TAS:ReactomePblood coagulation
GO:0016477 TAS:UniProtKBPcell migration
GO:0006874 IEA:EnsemblPcellular calcium ion homeostasis
GO:0006935 TAS:ProtIncPchemotaxis
GO:0040016 IEA:EnsemblPembryonic cleavage
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007186 TAS:UniProtKBPG-protein coupled receptor signaling pathway
GO:0007156 IEA:EnsemblPhomophilic cell adhesion via plasma membrane adhesion molecules
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0014065 TAS:UniProtKBPphosphatidylinositol 3-kinase signaling
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0030168 TAS:UniProtKBPplatelet activation
GO:0070527 TAS:UniProtKBPplatelet aggregation
GO:0010508 TAS:UniProtKBPpositive regulation of autophagy
GO:0001952 IEA:EnsemblPregulation of cell-matrix adhesion
GO:2000369 TAS:UniProtKBPregulation of clathrin-mediated endocytosis
GO:0007165 NAS:ProtIncPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0007169 TAS:UniProtKBPtransmembrane receptor protein tyrosine kinase signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_111155Cell-Cell communication
REACT_12051Cell surface interactions at the vascular wall
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_23832Nephrin interactions
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120870Phospholipid metabolism
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_121175PI Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_12526TCR signaling
REACT_12621Tie2 Signaling
REACT_264464VEGFA-VEGFR2 Pathway
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