MGP Database

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MGP002319

UniProt Annotations

Entry Information
Gene Namephospholipase D1, phosphatidylcholine-specific
Protein Entry
UniProt IDQ59EA4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=PLD1A; IsoId=Q13393-1; Sequence=Displayed; Name=PLD1B; IsoId=Q13393-2; Sequence=VSP_005020; Name=PLD1C; IsoId=Q13393-3; Sequence=VSP_005018, VSP_005019; Name=PLD1D; IsoId=Q13393-4; Sequence=VSP_005021, VSP_005022;
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
FunctionImplicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250}.
InteractionP23528:CFL1; NbExp=4; IntAct=EBI-2827556, EBI-352733;
SimilarityBelongs to the phospholipase D family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000305}.
SimilarityContains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationCytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Late endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
SubunitInteracts with PIP5K1B. {ECO:0000269|PubMed:11032811}.
Tissue SpecificityExpressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. {ECO:0000269|PubMed:9582313}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLD1ID43716ch3q26.html";
Web ResourceName=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";
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