MGP Database

MGP002431

Ontology/Pathway Information

Entrez Gene ID	5590
Gene Name	protein kinase C, zeta
Gene Symbol	PRKCZ
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0045179	IEA:Ensembl	C	apical cortex
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0043203	IEA:Ensembl	C	axon hillock
GO:0005911	IDA:UniProtKB	C	cell-cell junction
GO:0030054	TAS:Reactome	C	cell junction
GO:0031252	IEA:Ensembl	C	cell leading edge
GO:0005737	TAS:ProtInc	C	cytoplasm
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005768	IEA:UniProtKB-SubCell	C	endosome
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0031941	IEA:Ensembl	C	filamentous actin
GO:0016020	TAS:ProtInc	C	membrane
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0005815	IEA:Ensembl	C	microtubule organizing center
GO:0035748	IEA:Ensembl	C	myelin sheath abaxonal region
GO:0005635	IEA:Ensembl	C	nuclear envelope
GO:0016363	IEA:Ensembl	C	nuclear matrix
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	TAS:ProtInc	C	plasma membrane
GO:0005923	IEA:Ensembl	C	tight junction
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0043560	IC:BHF-UCL	F	insulin receptor substrate binding
GO:0015459	IEA:Ensembl	F	potassium channel regulator activity
GO:0004672	IDA:UniProtKB	F	protein kinase activity
GO:0004697	IEA:UniProtKB-EC	F	protein kinase C activity
GO:0004674	IDA:BHF-UCL	F	protein serine/threonine kinase activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0031532	IEA:Ensembl	P	actin cytoskeleton reorganization
GO:0031584	IEA:Ensembl	P	activation of phospholipase D activity
GO:0032148	IEA:Ensembl	P	activation of protein kinase B activity
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0016477	IEA:Ensembl	P	cell migration
GO:0030010	ISS:UniProtKB	P	establishment of cell polarity
GO:0006954	IEA:UniProtKB-KW	P	inflammatory response
GO:0008286	IEA:Ensembl	P	insulin receptor signaling pathway
GO:0007616	IEA:Ensembl	P	long-term memory
GO:0060291	ISS:UniProtKB	P	long-term synaptic potentiation
GO:0060081	IEA:Ensembl	P	membrane hyperpolarization
GO:0000226	IEA:Ensembl	P	microtubule cytoskeleton organization
GO:0043066	TAS:ProtInc	P	negative regulation of apoptotic process
GO:0051346	IEA:Ensembl	P	negative regulation of hydrolase activity
GO:0046627	IMP:BHF-UCL	P	negative regulation of insulin receptor signaling pathway
GO:0050732	IMP:BHF-UCL	P	negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333	IMP:BHF-UCL	P	negative regulation of protein complex assembly
GO:1990138	IEA:Ensembl	P	neuron projection extension
GO:0018105	IDA:BHF-UCL	P	peptidyl-serine phosphorylation
GO:0030168	TAS:Reactome	P	platelet activation
GO:0001954	IEA:Ensembl	P	positive regulation of cell-matrix adhesion
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0070374	IMP:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:2000463	ISS:UniProtKB	P	positive regulation of excitatory postsynaptic membrane potential
GO:0046326	IEA:Ensembl	P	positive regulation of glucose import
GO:0046628	ISS:UniProtKB	P	positive regulation of insulin receptor signaling pathway
GO:2001181	ISS:UniProtKB	P	positive regulation of interleukin-10 secretion
GO:2000667	ISS:UniProtKB	P	positive regulation of interleukin-13 secretion
GO:0032753	ISS:UniProtKB	P	positive regulation of interleukin-4 production
GO:2000664	ISS:UniProtKB	P	positive regulation of interleukin-5 secretion
GO:0051092	ISS:UniProtKB	P	positive regulation of NF-kappaB transcription factor activity
GO:2000553	ISS:UniProtKB	P	positive regulation of T-helper 2 cell cytokine production
GO:0045630	ISS:UniProtKB	P	positive regulation of T-helper 2 cell differentiation
GO:0051291	IEA:Ensembl	P	protein heterooligomerization
GO:0070528	IEA:Ensembl	P	protein kinase C signaling
GO:0072659	IEA:Ensembl	P	protein localization to plasma membrane
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0007179	TAS:Reactome	P	transforming growth factor beta receptor signaling pathway
GO:0047496	IEA:Ensembl	P	vesicle transport along microtubule

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_1695	GPVI-mediated activation cascade
REACT_604	Hemostasis
REACT_169398	Loss of Function of SMAD2/3 in Cancer
REACT_169219	Loss of Function of SMAD4 in Cancer
REACT_169311	Loss of Function of TGFBR1 in Cancer
REACT_169435	Loss of Function of TGFBR2 in Cancer
REACT_798	Platelet activation, signaling and aggregation
REACT_6844	Signaling by TGF-beta Receptor Complex
REACT_169122	Signaling by TGF-beta Receptor Complex in Cancer
REACT_12529	Signaling by VEGF
REACT_111102	Signal Transduction
REACT_169165	SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103	SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107	SMAD4 MH2 Domain Mutants in Cancer
REACT_120726	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263	TGFBR1 KD Mutants in Cancer
REACT_169445	TGFBR1 LBD Mutants in Cancer
REACT_169440	TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192	TGFBR2 MSI Frameshift Mutants in Cancer
REACT_264464	VEGFA-VEGFR2 Pathway
REACT_264273	VEGFR2 mediated cell proliferation

SMP Pathway Links

SMP ID	Description
SMP00320	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine