MGP Database

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MGP002432

Ontology/Pathway Information

Entrez Gene ID5591
Gene Nameprotein kinase, DNA-activated, catalytic polypeptide
Gene Symbol PRKDC
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005958 IDA:MGICDNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0070419 IDA:UniProtKBCnonhomologous end joining complex
GO:0005730 IEA:UniProtKB-SubCellCnucleolus
GO:0005654 IDA:HPACnucleoplasm
GO:0005667 IDA:BHF-UCLCtranscription factor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003677 IEA:UniProtKB-KWFDNA binding
GO:0004677 IDA:MGIFDNA-dependent protein kinase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:BHF-UCLFprotein serine/threonine kinase activity
GO:0008134 IPI:BHF-UCLFtranscription factor binding
GO:0002326 IEA:EnsemblPB cell lineage commitment
GO:0007420 IEA:EnsemblPbrain development
GO:0006464 TAS:ProtIncPcellular protein modification process
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0006281 TAS:ReactomePDNA repair
GO:0006302 TAS:ReactomePdouble-strand break repair
GO:0000724 IBA:GO_CentralPdouble-strand break repair via homologous recombination
GO:0006303 TAS:ReactomePdouble-strand break repair via nonhomologous end joining
GO:0035234 IEA:EnsemblPectopic germ cell programmed cell death
GO:0007507 IEA:EnsemblPheart development
GO:0033152 IEA:EnsemblPimmunoglobulin V(D)J recombination
GO:0045087 TAS:ReactomePinnate immune response
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0001933 ISS:UniProtKBPnegative regulation of protein phosphorylation
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0002328 IEA:EnsemblPpro-B cell differentiation
GO:0031648 IEA:EnsemblPprotein destabilization
GO:0042752 ISS:UniProtKBPregulation of circadian rhythm
GO:0010332 IEA:EnsemblPresponse to gamma radiation
GO:0048511 IEA:UniProtKB-KWPrhythmic process
GO:0072431 IMP:UniProtKBPsignal transduction involved in mitotic G1 DNA damage checkpoint
GO:0001756 IEA:EnsemblPsomitogenesis
GO:0033077 IEA:EnsemblPT cell differentiation in thymus
GO:0002360 IEA:EnsemblPT cell lineage commitment
GO:0033153 IEA:EnsemblPT cell receptor V(D)J recombination
GO:0000723 IEA:EnsemblPtelomere maintenance
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_216DNA Repair
REACT_2054Double-Strand Break Repair
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_163993IRF3-mediated induction of type I IFN
REACT_1022Nonhomologous End-joining (NHEJ)
REACT_1201Processing of DNA ends prior to end rejoining
REACT_147841STING mediated induction of host immune responses
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