MGP Database

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MGP002440

Ontology/Pathway Information

Entrez Gene ID5601
Gene Namemitogen-activated protein kinase 9
Gene Symbol MAPK9
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008656 IEA:EnsemblFcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0004705 IDA:UniProtKBFJUN kinase activity
GO:0008134 IDA:UniProtKBFtranscription factor binding
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0071347 IEA:EnsemblPcellular response to interleukin-1
GO:0071222 IEA:EnsemblPcellular response to lipopolysaccharide
GO:0071356 IEA:EnsemblPcellular response to tumor necrosis factor
GO:0034644 IEA:EnsemblPcellular response to UV
GO:0007417 IEA:EnsemblPcentral nervous system development
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0007254 IDA:UniProtKBPJNK cascade
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0031175 IEA:EnsemblPneuron projection development
GO:2001235 IEA:EnsemblPpositive regulation of apoptotic signaling pathway
GO:0010770 IEA:EnsemblPpositive regulation of cell morphogenesis involved in differentiation
GO:0032722 IEA:EnsemblPpositive regulation of chemokine production
GO:0010628 IMP:BHF-UCLPpositive regulation of gene expression
GO:0010744 IMP:BHF-UCLPpositive regulation of macrophage derived foam cell differentiation
GO:0045429 IEA:EnsemblPpositive regulation of nitric oxide biosynthetic process
GO:0051770 IEA:EnsemblPpositive regulation of nitric-oxide synthase biosynthetic process
GO:0031394 IEA:EnsemblPpositive regulation of prostaglandin biosynthetic process
GO:0032308 IEA:EnsemblPpositive regulation of prostaglandin secretion
GO:0001934 IEA:EnsemblPpositive regulation of protein phosphorylation
GO:0045893 IEA:EnsemblPpositive regulation of transcription, DNA-templated
GO:0006626 IEA:EnsemblPprotein targeting to mitochondrion
GO:0046328 IEA:EnsemblPregulation of JNK cascade
GO:0031396 IEA:EnsemblPregulation of protein ubiquitination
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0014075 IEA:EnsemblPresponse to amine
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0042493 IEA:EnsemblPresponse to drug
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0006950 TAS:ProtIncPresponse to stress
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_21326Activation of the AP-1 family of transcription factors
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_169436Oxidative Stress Induced Senescence
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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