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MGP002445

UniProt Annotations

Entry Information
Gene Namemitogen-activated protein kinase kinase 3
Protein EntryMP2K3_HUMAN
UniProt IDP46734
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=3; Synonyms=3b; IsoId=P46734-1; Sequence=Displayed; Name=1; IsoId=P46734-2; Sequence=VSP_004878; Name=2; Synonyms=3c; IsoId=P46734-3; Sequence=VSP_004877;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
DiseaseNote=Defects in MAP2K3 may be involved in colon cancer.
Enzyme RegulationActivated by dual phosphorylation on Ser-218 and Thr-222.
FunctionDual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
InteractionQ9Y463:DYRK1B; NbExp=2; IntAct=EBI-602462, EBI-634187; Q5S007:LRRK2; NbExp=5; IntAct=EBI-602462, EBI-5323863; Q99683:MAP3K5; NbExp=2; IntAct=EBI-602462, EBI-476263; Q16539:MAPK14; NbExp=2; IntAct=EBI-602462, EBI-73946;
PtmAutophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2. {ECO:0000269|PubMed:8622669}.
PtmYersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:19413330, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:22814378}.
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SubunitBinds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ. {ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:16709866, ECO:0000269|PubMed:16728640}.
Tissue SpecificityAbundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
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