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MGP002512

UniProt Annotations

Entry Information
Gene Nameprostaglandin D2 receptor (DP)
Protein EntryPD2R_HUMAN
UniProt IDQ13258
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13258-1; Sequence=Displayed; Name=2; IsoId=Q13258-2; Sequence=VSP_055141, VSP_055142; Note=No experimental confirmation available. Derived from EST data.;
DiseaseAsthma-related traits 1 (ASRT1) [MIM:607277]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269|PubMed:15496624}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionReceptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO:0000269|PubMed:11082108, ECO:0000269|PubMed:6302737}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/apobec3f/";
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