MGP Database

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MGP002527

Ontology/Pathway Information

Entrez Gene ID5747
Gene Nameprotein tyrosine kinase 2
Gene Symbol PTK2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IEA:EnsemblCapical plasma membrane
GO:0005938 IEA:UniProtKB-SubCellCcell cortex
GO:0005737 IDA:HPACcytoplasm
GO:0005856 IEA:InterProCcytoskeleton
GO:0005829 IDA:UniProtKBCcytosol
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005925 IDA:HPACfocal adhesion
GO:0030027 IEA:EnsemblClamellipodium
GO:0005815 IEA:UniProtKB-SubCellCmicrotubule organizing center
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0001725 IDA:UniProtKBCstress fiber
GO:0003779 IDA:BHF-UCLFactin binding
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008432 IDA:BHF-UCLFJUN kinase binding
GO:0004715 IDA:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0004672 TAS:ReactomeFprotein kinase activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004713 IEA:UniProtKB-KWFprotein tyrosine kinase activity
GO:0005102 IBA:GO_CentralFreceptor binding
GO:0042169 IPI:UniProtKBFSH2 domain binding
GO:0004871 IEA:InterProFsignal transducer activity
GO:0001525 TAS:UniProtKBPangiogenesis
GO:0006915 TAS:ReactomePapoptotic process
GO:0007411 TAS:UniProtKBPaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0048870 TAS:UniProtKBPcell motility
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0021955 IEA:EnsemblPcentral nervous system neuron axonogenesis
GO:0007010 IBA:GO_CentralPcytoskeleton organization
GO:0009790 TAS:UniProtKBPembryo development
GO:0043542 IEA:EnsemblPendothelial cell migration
GO:0048013 IDA:UniProtKBPephrin receptor signaling pathway
GO:0007173 IBA:GO_CentralPepidermal growth factor receptor signaling pathway
GO:0030010 TAS:UniProtKBPestablishment of cell polarity
GO:0040023 IEA:EnsemblPestablishment of nucleus localization
GO:0030198 IEA:EnsemblPextracellular matrix organization
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0060396 IDA:BHF-UCLPgrowth hormone receptor signaling pathway
GO:0003007 TAS:UniProtKBPheart morphogenesis
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0007229 IDA:UniProtKBPintegrin-mediated signaling pathway
GO:0000226 IEA:EnsemblPmicrotubule cytoskeleton organization
GO:2000811 IMP:UniProtKBPnegative regulation of anoikis
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0050771 IEA:EnsemblPnegative regulation of axonogenesis
GO:0022408 IDA:BHF-UCLPnegative regulation of cell-cell adhesion
GO:0046621 IEA:EnsemblPnegative regulation of organ growth
GO:0051964 IEA:EnsemblPnegative regulation of synapse assembly
GO:0038007 TAS:UniProtKBPnetrin-activated signaling pathway
GO:0001764 IEA:EnsemblPneuron migration
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0001890 TAS:UniProtKBPplacenta development
GO:0030168 TAS:ReactomePplatelet activation
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0008284 ISS:UniProtKBPpositive regulation of cell proliferation
GO:0043552 TAS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0045860 IMP:UniProtKBPpositive regulation of protein kinase activity
GO:0051897 IMP:UniProtKBPpositive regulation of protein kinase B signaling
GO:0001934 IMP:UniProtKBPpositive regulation of protein phosphorylation
GO:2000060 ISS:UniProtKBPpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0033628 IDA:UniProtKBPregulation of cell adhesion mediated by integrin
GO:0042127 IMP:UniProtKBPregulation of cell proliferation
GO:0008360 IMP:UniProtKBPregulation of cell shape
GO:0051493 TAS:UniProtKBPregulation of cytoskeleton organization
GO:0010594 TAS:UniProtKBPregulation of endothelial cell migration
GO:0051893 TAS:UniProtKBPregulation of focal adhesion assembly
GO:0045667 IMP:UniProtKBPregulation of osteoblast differentiation
GO:0032319 TAS:UniProtKBPregulation of Rho GTPase activity
GO:0007172 IEA:InterProPsignal complex assembly
GO:0007179 IDA:UniProtKBPtransforming growth factor beta receptor signaling pathway
GO:0001570 IEA:EnsemblPvasculogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_18266Axon guidance
REACT_111155Cell-Cell communication
REACT_22351DCC mediated attractive signaling
REACT_111045Developmental Biology
REACT_264548EPHA-mediated growth cone collapse
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_15523Integrin alphaIIb beta3 signaling
REACT_18334NCAM signaling for neurite out-growth
REACT_22237Netrin-1 signaling
REACT_22384Netrin mediated repulsion signals
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_268456Programmed Cell Death
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_12529Signaling by VEGF
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
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