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MGP002575

Record overview

MGPD IDMGP002575
Gene ID5901
SpeciesHomo sapiens (Human)
Gene NameRAN, member RAS oncogene family
Gene Symbol RAN
SynonymsTC4; Gsp1; ARA24;
Alternate namesGTP-binding nuclear protein Ran; GTPase Ran; OK/SW-cl.81; RanGTPase; androgen receptor-associated protein 24; guanosine triphosphatase Ran; member RAS oncogene family; ras-like protein TC4; ras-related nuclear protein;
Chromosome12
Map Location12q24.3
SummaryRAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RAN

Proteins

GTP-binding nuclear protein Ran isoform 1
Refseq ID:NP_006316
Protein GI:5453555
UniProt ID:P62826
mRNA ID:NM_006325
Length:216
RefSeq Status:
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKN
VPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHD
LEVAQTTALPDEDDDL
 
GTP-binding nuclear protein Ran isoform 2
Refseq ID:NP_001287726
Protein GI:663853401
UniProt ID:P62826
mRNA ID:NM_001300797
Length:128
RefSeq Status:
MFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVV
MDPALAAQYEHDLEVAQTTALPDEDDDL
 
GTP-binding nuclear protein Ran isoform 2
Refseq ID:NP_001287725
Protein GI:663855578
UniProt ID:P62826
mRNA ID:NM_001300796
Length:128
RefSeq Status:
Protein sequence is identical to GI:663853401 (mRNA isoform)
 
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