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MGP002581

UniProt Annotations

Entry Information
Gene NameRAP1 GTPase activating protein
Protein EntryRPGP1_HUMAN
UniProt IDP47736
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P47736-1; Sequence=Displayed; Name=2; IsoId=P47736-2; Sequence=VSP_035256, VSP_035257; Name=3; IsoId=P47736-3; Sequence=VSP_040260, VSP_040261; Note=Contains a phosphoserine at position 17.; Name=4; IsoId=P47736-4; Sequence=VSP_047025; Note=No experimental confirmation available.;
FunctionGTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}.
InductionBy 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells. {ECO:0000269|PubMed:9346962}.
InteractionP61224:RAP1B; NbExp=3; IntAct=EBI-722307, EBI-358143;
Sequence CautionSequence=AAH54490.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA32319.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 GoLoco domain. {ECO:0000255|PROSITE- ProRule:PRU00097}.
SimilarityContains 1 Rap-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00165}.
Subcellular LocationGolgi apparatus membrane; Peripheral membrane protein.
SubunitHomodimer and heterodimer with RAP1B. {ECO:0000269|PubMed:15141215, ECO:0000269|PubMed:18309292}.
Tissue SpecificitySignificant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. {ECO:0000269|PubMed:9346962}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAP1GAPID42043ch1p36.html";
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