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MGP002605

UniProt Annotations

Entry Information
Gene Namev-rel avian reticuloendotheliosis viral oncogene homolog
Protein EntryREL_HUMAN
UniProt IDQ04864
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q04864-1; Sequence=Displayed; Name=2; IsoId=Q04864-2; Sequence=VSP_055857; Note=No experimental confirmation available.;
FunctionProto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
InteractionQ8N668:COMMD1; NbExp=3; IntAct=EBI-307352, EBI-1550112; Q00653:NFKB2; NbExp=3; IntAct=EBI-307352, EBI-307326;
SimilarityContains 1 RHD (Rel-like) domain. {ECO:0000255|PROSITE-ProRule:PRU00265}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitComponent of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c- Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. {ECO:0000250, ECO:0000269|PubMed:15024091, ECO:0000269|PubMed:15102766, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:8152812, ECO:0000269|PubMed:9056676, ECO:0000269|PubMed:9315679}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RELID322.html";
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