MGP Database

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MGP002639

Ontology/Pathway Information

Entrez Gene ID6093
Gene NameRho-associated, coiled-coil containing protein kinase 1
Gene Symbol ROCK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0032059 IEA:UniProtKB-SubCellCbleb
GO:0005814 IEA:UniProtKB-SubCellCcentriole
GO:0005856 ISS:UniProtKBCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0030027 ISS:UniProtKBClamellipodium
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0001726 ISS:UniProtKBCruffle
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0030036 TAS:ProtIncPactin cytoskeleton organization
GO:0003383 IEA:EnsemblPapical constriction
GO:0006915 TAS:ReactomePapoptotic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0032060 IEA:EnsemblPbleb assembly
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0007159 IDA:BHF-UCLPleukocyte cell-cell adhesion
GO:0050900 IDA:BHF-UCLPleukocyte migration
GO:0050901 IDA:BHF-UCLPleukocyte tethering or rolling
GO:0022614 IDA:BHF-UCLPmembrane to membrane docking
GO:0051451 ISS:UniProtKBPmyoblast migration
GO:0016525 IMP:UniProtKBPnegative regulation of angiogenesis
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0051894 ISS:UniProtKBPpositive regulation of focal adhesion assembly
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0032956 TAS:UniProtKBPregulation of actin cytoskeleton organization
GO:0030155 TAS:UniProtKBPregulation of cell adhesion
GO:2000145 TAS:UniProtKBPregulation of cell motility
GO:2000114 TAS:UniProtKBPregulation of establishment of cell polarity
GO:0051893 TAS:UniProtKBPregulation of focal adhesion assembly
GO:0045616 IMP:UniProtKBPregulation of keratinocyte differentiation
GO:0051492 TAS:UniProtKBPregulation of stress fiber assembly
GO:0007266 TAS:ProtIncPRho protein signal transduction
GO:0007165 TAS:ProtIncPsignal transduction
GO:0006939 TAS:UniProtKBPsmooth muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_264548EPHA-mediated growth cone collapse
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_268456Programmed Cell Death
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19271Semaphorin interactions
REACT_14797Signaling by GPCR
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
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