MGP Database

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MGP002914

UniProt Annotations

Entry Information
Gene Nameslit homolog 3 (Drosophila)
Protein EntrySLIT3_HUMAN
UniProt IDO75094
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=O75094-1; Sequence=Displayed; Name=2; IsoId=O75094-2; Sequence=VSP_009714; Name=3; IsoId=O75094-3; Sequence=VSP_009715; Name=4; IsoId=O75094-4; Sequence=VSP_054798; Note=No experimental confirmation available.;
FunctionMay act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Sequence CautionSequence=BAA32466.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB59249.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
SimilarityContains 1 CTCK (C-terminal cystine knot-like) domain. {ECO:0000255|PROSITE-ProRule:PRU00039}.
SimilarityContains 1 laminin G-like domain. {ECO:0000255|PROSITE-ProRule:PRU00122}.
SimilarityContains 20 LRR (leucine-rich) repeats. {ECO:0000305}.
SimilarityContains 4 LRRCT domains. {ECO:0000305}.
SimilarityContains 4 LRRNT domains. {ECO:0000305}.
SimilarityContains 9 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationSecreted {ECO:0000250}.
Tissue SpecificityPredominantly expressed in thyroid. {ECO:0000269|PubMed:9813312}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SLIT3ID50515ch5q34.html";
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