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MGP002984

UniProt Annotations

Entry Information
Gene Namesignal recognition particle 68kDa
Protein EntrySRP68_HUMAN
UniProt IDQ9UHB9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UHB9-1; Sequence=Displayed; Name=2; IsoId=Q9UHB9-2; Sequence=VSP_008347; Note=No experimental confirmation available.; Name=3; IsoId=Q9UHB9-3; Sequence=VSP_045132; Name=4; IsoId=Q9UHB9-4; Sequence=VSP_046944; Note=No experimental confirmation available.;
DomainThe RNA-binding domain is located near the N-terminus.
FunctionSignal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
SimilarityBelongs to the SRP68 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus, nucleolus.
SubunitSignal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
Web ResourceName=Wikipedia; Note=Signal recognition particle entry; URL="http://en.wikipedia.org/wiki/Signal-recognition_particle";
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