MGP Database

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MGP003014

Ontology/Pathway Information

Entrez Gene ID6794
Gene Nameserine/threonine kinase 11
Gene Symbol STK11
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:MGICcytoplasm
GO:0005829 ISS:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 ISS:UniProtKBCmembrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005634 IDA:MGICnucleus
GO:0036398 IEA:EnsemblCTCR signalosome
GO:0005524 IDA:UniProtKBFATP binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0002039 IDA:UniProtKBFp53 binding
GO:0030295 IDA:UniProtKBFprotein kinase activator activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0032147 IDA:MGIPactivation of protein kinase activity
GO:0043276 IMP:BHF-UCLPanoikis
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0007409 IEA:EnsemblPaxonogenesis
GO:0060070 IEA:EnsemblPcanonical Wnt signaling pathway
GO:0007050 IDA:UniProtKBPcell cycle arrest
GO:0006974 IEA:UniProtKB-KWPcellular response to DNA damage stimulus
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0030010 ISS:UniProtKBPestablishment of cell polarity
GO:0042593 ISS:UniProtKBPglucose homeostasis
GO:0051645 IEA:EnsemblPGolgi localization
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0072332 IDA:UniProtKBPintrinsic apoptotic signaling pathway by p53 class mediator
GO:0030308 ISS:UniProtKBPnegative regulation of cell growth
GO:0008285 IMP:UniProtKBPnegative regulation of cell proliferation
GO:0060770 IEA:EnsemblPnegative regulation of epithelial cell proliferation involved in prostate gland development
GO:0050772 IEA:EnsemblPpositive regulation of axonogenesis
GO:0045722 IEA:EnsemblPpositive regulation of gluconeogenesis
GO:0050731 IEA:EnsemblPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0030511 IMP:BHF-UCLPpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0045059 IEA:EnsemblPpositive thymic T cell selection
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0001558 ISS:UniProtKBPregulation of cell growth
GO:0042304 TAS:ReactomePregulation of fatty acid biosynthetic process
GO:0051896 IEA:EnsemblPregulation of protein kinase B signaling
GO:0030111 IEA:EnsemblPregulation of Wnt signaling pathway
GO:0033762 IEA:EnsemblPresponse to glucagon
GO:0010212 ISS:UniProtKBPresponse to ionizing radiation
GO:0033993 IEA:EnsemblPresponse to lipid
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007286 IEA:EnsemblPspermatid development
GO:0050852 IEA:EnsemblPT cell receptor signaling pathway
GO:0036399 IEA:EnsemblPTCR signalosome assembly
GO:0001894 IEA:EnsemblPtissue homeostasis
GO:0001944 ISS:UniProtKBPvasculature development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1988AMPK inhibits chREBP transcriptional activation activity
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_150210IGF1R signaling cascade
REACT_1195Insulin receptor signalling cascade
REACT_1505Integration of energy metabolism
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111217Metabolism
REACT_6838mTOR signalling
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_21285Regulation of AMPK activity via LKB1
REACT_498Signaling by Insulin receptor
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
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