MGP Database

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MGP003037

Ontology/Pathway Information

Entrez Gene ID6850
Gene Namespleen tyrosine kinase
Gene Symbol SYK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0019815 IEA:EnsemblCB cell receptor complex
GO:0005737 IDA:MGICcytoplasm
GO:0005829 IC:UniProtKBCcytosol
GO:0032009 ISS:UniProtKBCearly phagosome
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005634 IDA:MGICnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043234 IDA:MGICprotein complex
GO:0042101 IDA:MGICT cell receptor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005178 IPI:UniProtKBFintegrin binding
GO:0004715 IDA:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0004672 NAS:UniProtKBFprotein kinase activity
GO:0004674 IDA:MGIFprotein serine/threonine kinase activity
GO:0004713 EXP:ReactomeFprotein tyrosine kinase activity
GO:0004716 IEA:EnsemblFreceptor signaling protein tyrosine kinase activity
GO:0007257 IEA:EnsemblPactivation of JUN kinase activity
GO:0002250 ISS:UniProtKBPadaptive immune response
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0050853 ISS:UniProtKBPB cell receptor signaling pathway
GO:0043366 IEA:EnsemblPbeta selection
GO:0007596 TAS:ReactomePblood coagulation
GO:0048514 ISS:UniProtKBPblood vessel morphogenesis
GO:0008283 TAS:ProtIncPcell proliferation
GO:0071226 ISS:UniProtKBPcellular response to molecule of fungal origin
GO:0042742 ISS:UniProtKBPdefense response to bacterium
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0006954 IBA:GO_CentralPinflammatory response
GO:0045087 ISS:UniProtKBPinnate immune response
GO:0007229 ISS:UniProtKBPintegrin-mediated signaling pathway
GO:0002366 ISS:UniProtKBPleukocyte activation involved in immune response
GO:0007159 IDA:UniProtKBPleukocyte cell-cell adhesion
GO:0019370 IEA:EnsemblPleukotriene biosynthetic process
GO:0001945 ISS:UniProtKBPlymph vessel development
GO:0002281 ISS:UniProtKBPmacrophage activation involved in immune response
GO:0002283 ISS:UniProtKBPneutrophil activation involved in immune response
GO:0030593 IDA:UniProtKBPneutrophil chemotaxis
GO:0009887 TAS:ProtIncPorgan morphogenesis
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0046638 IEA:EnsemblPpositive regulation of alpha-beta T cell differentiation
GO:0046641 IBA:GO_CentralPpositive regulation of alpha-beta T cell proliferation
GO:0045579 IBA:GO_CentralPpositive regulation of B cell differentiation
GO:0045780 ISS:UniProtKBPpositive regulation of bone resorption
GO:0050850 IEA:EnsemblPpositive regulation of calcium-mediated signaling
GO:0033630 ISS:UniProtKBPpositive regulation of cell adhesion mediated by integrin
GO:0050715 IEA:EnsemblPpositive regulation of cytokine secretion
GO:0045588 IEA:EnsemblPpositive regulation of gamma-delta T cell differentiation
GO:0045425 IEA:EnsemblPpositive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045401 IEA:EnsemblPpositive regulation of interleukin-3 biosynthetic process
GO:0043306 IBA:GO_CentralPpositive regulation of mast cell degranulation
GO:0050731 IEA:EnsemblPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0006468 ISS:UniProtKBPprotein phosphorylation
GO:0090237 ISS:UniProtKBPregulation of arachidonic acid secretion
GO:0070372 ISS:UniProtKBPregulation of ERK1 and ERK2 cascade
GO:0043313 ISS:UniProtKBPregulation of neutrophil degranulation
GO:0050764 ISS:UniProtKBPregulation of phagocytosis
GO:0010543 ISS:UniProtKBPregulation of platelet activation
GO:0090330 ISS:UniProtKBPregulation of platelet aggregation
GO:0051090 IMP:MGIPregulation of sequence-specific DNA binding transcription factor activity
GO:0032928 ISS:UniProtKBPregulation of superoxide anion generation
GO:0002554 ISS:UniProtKBPserotonin secretion by platelet
GO:0042991 IMP:MGIPtranscription factor import into nucleus
GO:0007169 IBA:GO_CentralPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160274FCGR activation
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_15523Integrin alphaIIb beta3 signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_160158Role of phospholipids in phagocytosis
REACT_22232Signaling by Interleukins
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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