MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003097

Record overview

MGPD IDMGP003097
Gene ID6997
SpeciesHomo sapiens (Human)
Gene Nameteratocarcinoma-derived growth factor 1
Gene Symbol TDGF1
SynonymsCR; CRGF; CRIPTO;
Alternate namesteratocarcinoma-derived growth factor 1; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;
Chromosome3
Map Location3p21.31
SummaryThis gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for TDGF1

Proteins

teratocarcinoma-derived growth factor 1 isoform 1 precursor
Refseq ID:NP_003203
Protein GI:4507425
UniProt ID:P13385
mRNA ID:NM_003212
Length:188
RefSeq Status:
MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPS
FYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGICLSIQSYY
 
sig_peptide: 1..30
calculated_mol_wt: 3423
peptide sequence: 
MDCRKMARFSYSVIWIMAISKVFELGLVAG

mat_peptide: 31..188
product: teratocarcinoma-derived growth factor 1 isoform 1
calculated_mol_wt: 17764
peptide sequence: 
LGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSL
CKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGICLSIQSYY
 
teratocarcinoma-derived growth factor 1 isoform 2
Refseq ID:NP_001167607
Protein GI:292494883
UniProt ID:P13385
mRNA ID:NM_001174136
Length:172
RefSeq Status:
MAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCG
SVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGICLSIQSYY
 
sig_peptide: 1..30
calculated_mol_wt: 3423
peptide sequence: 
MDCRKMARFSYSVIWIMAISKVFELGLVAG

mat_peptide: 31..188
product: teratocarcinoma-derived growth factor 1 isoform 1
calculated_mol_wt: 17764
peptide sequence: 
LGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSL
CKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGICLSIQSYY
 
  logo