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MGP003101

UniProt Annotations

Entry Information
Gene NameTEA domain family member 4
Protein EntryTEAD4_HUMAN
UniProt IDQ15561
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15561-1; Sequence=Displayed; Name=2; IsoId=Q15561-2; Sequence=VSP_043099; Note=No experimental confirmation available.; Name=3; IsoId=Q15561-3; Sequence=VSP_045657; Note=No experimental confirmation available.;
FunctionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
InteractionQ9GZV5:WWTR1; NbExp=2; IntAct=EBI-747736, EBI-747743;
Sequence CautionSequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
SimilarityContains 1 TEA DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00505}.
Subcellular LocationNucleus.
SubunitInteracts with YAP1 and WWTR1/TAZ. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877, ECO:0000269|PubMed:20123908}.
Tissue SpecificityPreferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
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