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MGP003106

Record overview

MGPD IDMGP003106
Gene ID7014
SpeciesHomo sapiens (Human)
Gene Nametelomeric repeat binding factor 2
Gene Symbol TERF2
SynonymsTRF2; TRBF2;
Alternate namestelomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; telomeric DNA-binding protein; telomeric repeat binding protein 2;
Chromosome16
Map Location16q22.1
SummaryThis gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TERF2

Proteins

telomeric repeat-binding factor 2
Refseq ID:NP_005643
Protein GI:429535832
UniProt ID:Q15554
mRNA ID:NM_005652
Length:542
RefSeq Status:
MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLK
FYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVK
EAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDK
QPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMT
ISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWV
KAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
 
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