MGP Database

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MGP003123

Ontology/Pathway Information

Entrez Gene ID7046
Gene Nametransforming growth factor, beta receptor 1
Gene Symbol TGFBR1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005768 IEA:EnsemblCendosome
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0043235 IDA:BHF-UCLCreceptor complex
GO:0005923 IDA:UniProtKBCtight junction
GO:0070022 IC:BHF-UCLCtransforming growth factor beta receptor homodimeric complex
GO:0005524 IDA:HGNCFATP binding
GO:0070411 IPI:BHF-UCLFI-SMAD binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004672 IDA:BHF-UCLFprotein kinase activity
GO:0004674 IDA:HGNCFprotein serine/threonine kinase activity
GO:0004702 IEA:InterProFreceptor signaling protein serine/threonine kinase activity
GO:0046332 IDA:HGNCFSMAD binding
GO:0005024 IDA:BHF-UCLFtransforming growth factor beta-activated receptor activity
GO:0050431 IDA:BHF-UCLFtransforming growth factor beta binding
GO:0005025 IDA:BHF-UCLFtransforming growth factor beta receptor activity, type I
GO:0005114 IDA:BHF-UCLFtype II transforming growth factor beta receptor binding
GO:0000186 IDA:BHF-UCLPactivation of MAPKK activity
GO:0001525 IEA:EnsemblPangiogenesis
GO:0009952 ISS:BHF-UCLPanterior/posterior pattern specification
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0048844 ISS:BHF-UCLPartery morphogenesis
GO:0001824 IEA:EnsemblPblastocyst development
GO:0007050 TAS:UniProtKBPcell cycle arrest
GO:0048870 IMP:BHF-UCLPcell motility
GO:0071560 IDA:BHF-UCLPcellular response to transforming growth factor beta stimulus
GO:0030199 ISS:BHF-UCLPcollagen fibril organization
GO:0048701 ISS:BHF-UCLPembryonic cranial skeleton morphogenesis
GO:0043542 IEA:EnsemblPendothelial cell migration
GO:0001837 IDA:UniProtKBPepithelial to mesenchymal transition
GO:0043062 TAS:UniProtKBPextracellular structure organization
GO:0008354 ISS:BHF-UCLPgerm cell migration
GO:0007507 ISS:BHF-UCLPheart development
GO:0001701 ISS:BHF-UCLPin utero embryonic development
GO:0001822 ISS:BHF-UCLPkidney development
GO:0002088 IEA:EnsemblPlens development in camera-type eye
GO:0048762 TAS:UniProtKBPmesenchymal cell differentiation
GO:0032331 ISS:BHF-UCLPnegative regulation of chondrocyte differentiation
GO:0001937 IEA:EnsemblPnegative regulation of endothelial cell proliferation
GO:2001237 IMP:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0048663 ISS:BHF-UCLPneuron fate commitment
GO:0060021 ISS:BHF-UCLPpalate development
GO:0060017 ISS:BHF-UCLPparathyroid gland development
GO:0060389 IDA:BHF-UCLPpathway-restricted SMAD protein phosphorylation
GO:0018105 IDA:UniProtKBPpeptidyl-serine phosphorylation
GO:0018107 IDA:BHF-UCLPpeptidyl-threonine phosphorylation
GO:0060037 ISS:BHF-UCLPpharyngeal system development
GO:2001235 IDA:UniProtKBPpositive regulation of apoptotic signaling pathway
GO:0030307 IDA:BHF-UCLPpositive regulation of cell growth
GO:0008284 IMP:HGNCPpositive regulation of cell proliferation
GO:0051272 IMP:BHF-UCLPpositive regulation of cellular component movement
GO:0051491 IEA:EnsemblPpositive regulation of filopodium assembly
GO:0010862 IDA:BHF-UCLPpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897 IDA:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0060391 IDA:BHF-UCLPpositive regulation of SMAD protein import into nucleus
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0009791 IEA:EnsemblPpost-embryonic development
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0043393 IEA:EnsemblPregulation of protein binding
GO:0031396 IDA:UniProtKBPregulation of protein ubiquitination
GO:0006355 IDA:HGNCPregulation of transcription, DNA-templated
GO:0070723 IDA:BHF-UCLPresponse to cholesterol
GO:0007165 IDA:HGNCPsignal transduction
GO:0001501 ISS:BHF-UCLPskeletal system development
GO:0048705 ISS:BHF-UCLPskeletal system morphogenesis
GO:0048538 ISS:BHF-UCLPthymus development
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
GO:0042060 TAS:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
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