MGP Database

MGP003126

Ontology/Pathway Information

Entrez Gene ID	7054
Gene Name	tyrosine hydroxylase
Gene Symbol	TH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0009898	IDA:BHF-UCL	C	cytoplasmic side of plasma membrane
GO:0031410	IDA:BHF-UCL	C	cytoplasmic vesicle
GO:0005829	TAS:Reactome	C	cytosol
GO:0030425	IEA:Ensembl	C	dendrite
GO:0033162	IDA:BHF-UCL	C	melanosome membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0043005	IDA:BHF-UCL	C	neuron projection
GO:0005634	ISS:BHF-UCL	C	nucleus
GO:0043204	ISS:BHF-UCL	C	perikaryon
GO:0005790	IDA:BHF-UCL	C	smooth endoplasmic reticulum
GO:0008021	IEA:Ensembl	C	synaptic vesicle
GO:0043195	IEA:Ensembl	C	terminal bouton
GO:0016597	IEA:Ensembl	F	amino acid binding
GO:0035240	IEA:Ensembl	F	dopamine binding
GO:0019899	IPI:ParkinsonsUK-UCL	F	enzyme binding
GO:0008199	IEA:Ensembl	F	ferric iron binding
GO:0008198	IEA:Ensembl	F	ferrous iron binding
GO:0019825	IEA:Ensembl	F	oxygen binding
GO:0034617	IEA:Ensembl	F	tetrahydrobiopterin binding
GO:0004511	IDA:UniProtKB	F	tyrosine 3-monooxygenase activity
GO:0009653	TAS:ProtInc	P	anatomical structure morphogenesis
GO:0042423	TAS:Reactome	P	catecholamine biosynthetic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0071333	IEA:Ensembl	P	cellular response to glucose stimulus
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0071287	IEA:Ensembl	P	cellular response to manganese ion
GO:0071316	IEA:Ensembl	P	cellular response to nicotine
GO:0021987	IEA:Ensembl	P	cerebral cortex development
GO:0042745	IEA:Ensembl	P	circadian sleep/wake cycle
GO:0042416	IDA:BHF-UCL	P	dopamine biosynthetic process
GO:0006585	NAS:BHF-UCL	P	dopamine biosynthetic process from tyrosine
GO:0042755	IEA:Ensembl	P	eating behavior
GO:0048596	ISS:BHF-UCL	P	embryonic camera-type eye morphogenesis
GO:0042418	IDA:BHF-UCL	P	epinephrine biosynthetic process
GO:0042462	ISS:BHF-UCL	P	eye photoreceptor cell development
GO:0006631	IEA:Ensembl	P	fatty acid metabolic process
GO:0016137	IEA:Ensembl	P	glycoside metabolic process
GO:0007507	ISS:BHF-UCL	P	heart development
GO:0003007	NAS:BHF-UCL	P	heart morphogenesis
GO:0033076	IEA:Ensembl	P	isoquinoline alkaloid metabolic process
GO:0007612	ISS:BHF-UCL	P	learning
GO:0007626	ISS:BHF-UCL	P	locomotory behavior
GO:0007617	IEA:Ensembl	P	mating behavior
GO:0007613	ISS:BHF-UCL	P	memory
GO:0010259	IEA:Ensembl	P	multicellular organismal aging
GO:0042136	IEA:UniProtKB-KW	P	neurotransmitter biosynthetic process
GO:0042421	IDA:BHF-UCL	P	norepinephrine biosynthetic process
GO:0009887	ISS:BHF-UCL	P	organ morphogenesis
GO:0018963	IEA:Ensembl	P	phthalate metabolic process
GO:0052314	IEA:Ensembl	P	phytoalexin metabolic process
GO:0043473	TAS:BHF-UCL	P	pigmentation
GO:0008016	ISS:BHF-UCL	P	regulation of heart contraction
GO:0014823	IEA:Ensembl	P	response to activity
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0051412	IEA:Ensembl	P	response to corticosterone
GO:0051602	IEA:Ensembl	P	response to electrical stimulus
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0045471	IDA:BHF-UCL	P	response to ethanol
GO:0045472	IEA:Ensembl	P	response to ether
GO:0009635	IEA:Ensembl	P	response to herbicide
GO:0001666	IDA:BHF-UCL	P	response to hypoxia
GO:0035902	IEA:Ensembl	P	response to immobilization stress
GO:0009416	IEA:Ensembl	P	response to light stimulus
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0031667	IEA:Ensembl	P	response to nutrient levels
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0046684	IEA:Ensembl	P	response to pyrethroid
GO:0009651	IEA:Ensembl	P	response to salt stress
GO:0009414	IEA:Ensembl	P	response to water deprivation
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0035176	IEA:Ensembl	P	social behavior
GO:0006665	IEA:Ensembl	P	sphingolipid metabolic process
GO:0001963	ISS:BHF-UCL	P	synaptic transmission, dopaminergic
GO:0015842	IEA:Ensembl	P	synaptic vesicle amine transport
GO:0042214	IEA:Ensembl	P	terpene metabolic process
GO:0007601	ISS:BHF-UCL	P	visual perception

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_15513	Amine-derived hormones
REACT_15551	Catecholamine biosynthesis
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives

SMP Pathway Links

SMP ID	Description
SMP00170	Aromatic L-Aminoacid Decarboxylase Deficiency
SMP00012	Catecholamine Biosynthesis
SMP00497	Tyrosine hydroxylase deficiency